Double unit cord blood transplantation
نویسندگان
چکیده
منابع مشابه
One-unit versus two-unit cord-blood transplantation.
BACKGROUND Umbilical-cord blood has been used as the source of hematopoietic stem cells in an estimated 30,000 transplants. The limited number of hematopoietic cells in a single cord-blood unit prevents its use in recipients with larger body mass and results in delayed hematopoietic recovery and higher mortality. Therefore, we hypothesized that the greater numbers of hematopoietic cells in two ...
متن کاملImpact of ATG-containing reduced-intensity conditioning after single- or double-unit allogeneic cord blood transplantation.
We analyzed 661 adult patients who underwent single-unit (n = 226) or double-unit (n = 435) unrelated cord blood transplantation (UCBT) following a reduced-intensity conditioning (RIC) consisting of low-dose total body irradiation (TBI), cyclophosphamide, and fludarabine (Cy/Flu/TBI200). Eighty-two patients received rabbit antithymocyte globulin (ATG) as part of the conditioning regimen (ATG gr...
متن کاملAn in vivo model of double-unit cord blood transplantation that correlates with clinical engraftment.
Double-unit cord blood transplantation (DCBT) appears to enhance engraftment despite sustained hematopoiesis usually being derived from a single unit. To investigate DCBT biology, in vitro and murine models were established using cells from 39 patient grafts. Mononuclear cells (MNCs) and CD34(+) cells from each unit alone and in DCB combination were assessed for colony-forming cell and cobblest...
متن کاملThe effect of inter-unit HLA matching in double umbilical cord blood transplantation for acute leukemia
The effects of inter-unit HLA-match on early outcomes with regards to double cord blood transplantation have not been established. Therefore, we studied the effect of inter-unit HLA-mismatching on the outcomes of 449 patients with acute leukemia after double cord blood transplantation. Patients were divided into two groups: one group that included transplantations with inter-unit mismatch at 2 ...
متن کاملDominant unit CD34+ cell dose predicts engraftment after double-unit cord blood transplantation and is influenced by bank practice.
We investigated the unit characteristics associated with engraftment after double-unit cord blood (CB) transplantation (dCBT) and whether these could be reliably identified during unit selection. Cumulative incidence of neutrophil engraftment in 129 myeloablative dCBT recipients was 95% (95% confidence interval: 90-98%). When precryopreservation characteristics were analyzed, the dominant unit ...
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ژورنال
عنوان ژورنال: Chimerism
سال: 2010
ISSN: 1938-1956,1938-1964
DOI: 10.4161/chim.1.1.12141